The Clean Scientists of Clean Wellness, Relief Box (Omega-3 & Hyaluronic Acid)

CW Omega-3

Astaxanthin has antioxidant properties that provide the majority of its health benefits such as improved blood flow, increased energy levels, a lower rate of oxidative (toxin) damage to cells, DNA and cell protection by neutralizing oxidants; reduced growth of cancer cells, and a stronger immune system that better protects cells in the brain and eyes [6-11]. Astaxanthin supplementation also appears to boost the body’s absorption of fatty acids (omega-3), which increases mental and physical endurance [10]. Healthy levels of omega 3 fatty acids (DHA and EPA) support cognitive functions such as memory, focus, motivation, etc., and enhanced energy, while low omega 3 fatty acid levels are linked to mental fatigue [1-3]. In addition, omega-3 fatty acids improve age-related eye problems, support heart health, promote optimal cholesterol levels, and enhance mental health through its ability to help protect against dementia and age-related cognitive issues, and it targets depression, inattentiveness, and hyperactivity [1- 4].

CW Hyaluronic Acid

Sodium hyaluronate has powerful moisturizing and hydrating properties that are beneficial for the skin [12]. Vitamin C is a powerful antioxidant that penetrates the membrane of cells throughout the body, thereby boosting the health of skin, bone, tendon, and muscle cells as well as immune system function [13]. Camellia sinensis leaf extract contains antioxidants such as epigallocatechin-3-gallate (EGCG) which combat UV-induced DNA damage in the skin [16]. Jojoba seed oil and aloe barbadensis boost the body’s natural wound-healing processes [17,18].

CW Omega-3

Supporting health and normal brain function, eye health and normal vision, healthy stress levels and good moods, healthy cholesterol levels

CW Hyaluronic Acid

Skin soothing, moisturizing, hydrating, and rejuvenation [12-18]; Improved skin health [12-18]

CW Omega-3

Polyunsaturated fat such as omega-3 fatty acids help target inflammation as well as damage to eye cells that could lead to macular degeneration and dry eye syndrome [1-3]. The body cannot produce these types of essential acids on its own. In addition, omega fatty acids have neuroprotective properties that protect brain cells from different types of damage [4, 5]. Astaxanthin demonstrates potent antioxidant activity that supports cell membrane activity by protecting it from free radical and oxidative damage due to its ability to neutralize oxidants, this property helps enhance immune system’s ability to ward of illness-causing agents that can damage brain cells or eye cells [6]. In addition, it boosts the body's ability to use fatty acids (omega-3), which helps protect tissue throughout the body at the cellular level [9]. Furthermore, it improves arterial wall thickness, thereby enhancing blood flow to organs such as the brain [10]. It has anti-inflammatory properties that support overall health [11].

CW Hyaluronic Acid

Sodium hyaluronate hydrates the skin and helps it retain moisture [1]. Sodium Hyaluronate, which is a salt that is derived from hyaluronic acid, is more easily absorbed into the skin than hyaluronic acid [12]. Vitamin C acts directly upon collagen metabolism by stimulating the production of collagen and elastin fibers [13]. Collagen production is vital for healthy skin, bones, tendons, and muscles. Plant sources such as green tea and aloe vera also contain powerful bioflavonoids that combat cell damage that is linked to free radicals and they subsequently promote detoxification, which dramatically improves health [14,15]. Green Tea contains EGCG, which is an antioxidant that targets oxidative stress-induced skin damage [16]. JoJoba oil and aloe vera are beneficial due to their anti-aging, wound healing, and anti-inflammatory activity, and they also helps enhance the absorption of other topical agents [17, 18].

CW Omega-3

Key Ingredients:  EPA (850mg per day) and DHA (650 per day) with 1,500mg of omega-3s per daily serving, 4mg astaxanthin an antioxidant carotenoid from sea algae and 30mg concentrated fucoxanthin, an antioxidant from brown seaweed

All Ingredients:  Gelatin (bovine), Vegetable Glycerin, purified deep sea fish oil (anchovies, sardines, and mackerel with natural tocepherols Beeswax, Beta-Carotene, Natural Strawberry Flavoring, silicone dioxide, Non-GMO Soy Lecithin

CW Hyaluronic Acid

Key Ingredients:  Aloe Barbadensis Leaf Juice, Sodium Hyaluronate, Sodium Ascorbyl Phosphate, Camellia Sinensis Leaf Extract, Simmondsia Chinensis (Jojoba) Seed Oil (% were not listed)

All Ingredients:  Aqua, Aloe Barbadensis Leaf Juice, Sodium Hyaluronate*, Glycerin*, Sodium Ascorbyl Phosphate**, Camellia Sinensis Leaf Extract, Glycyrrhiza Glabra (Licorice) Root Extract, Ginkgo Biloba Leaf Extract, Punica Granatum Seed Extract, Argania Spinosa Kernel Oil, Simmondsia Chinensis (Jojoba) Seed Oil, Pelargonium Graveolens Flower Oil, Limnanthes Alba (Meadowfoam) Seed Oil, Hesperidin, Rosmarinus Officinalis (Rosemary) Leaf Extract, Centella Asiatica Extract, Hibiscus Rosa-Sinensis Flower Extract, Tocopherol*, Hydroxyethylcellulose*, Xanthan Gum*, Pentylene Glycol*, Caprylyl Glycol**, Ethylhexylglycerin**, Citral*, Citronellol*, Geraniol*, Linalool*. *Naturally Derived, **Safe Synthetic

CW Omega-3

Adults can take 2 soft gels per day (up to 6 soft gels daily). Take it with food and water.

CW Hyaluronic Acid

Massage a small amount onto cleansed and toned skin, allowing the serum to absorb completely. Follow with appropriate moisturizer.

CW Omega-3

[1] Chang CY, Ke DS, Chen JY. Essential fatty acids and human brain. Acta neurologica Taiwanica. 2009;18(4):231-241.
[2] McDougle DR, Watson JE, et al. Anti-inflammatory ω-3 endocannabinoid epoxides. Proc Natl Acad Sci U S A. 2017;114(30):E6034-E6043. 7.
[3] Basu A, Devaraj S, Jialal I. Dietary factors that promote or retard inflammation. Arterioscler Thromb Vasc Biol. 2006;26(5):995-1001.
[4] Yoneyama S, Miura K, et al. Dietary intake of fatty acids and serum C-reactive protein in Japanese. J Epidemiol. 2007;17(3):86-92.
[5] Feller, S.E.; Gawrisch, K.; MacKerell, A.D., Jr. Polyunsaturated fatty acids in lipid bilayers: Intrinsic and environmental contributions to their unique physical properties. J. Am. Chem. Soc. 2002;124:318-326.
[6] Kidd P. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Altern Med Rev. 2011;16(4):355-64.
[7] Teo IT, Chui CH, Tang JC, et al. Antiproliferation and induction of cell death of Phaffia rhodozyma (Xanthophyllomyces dendrorhous) extract fermented by brewer malt waste on breast cancer cells. Int J Mol Med. 2005;16(5):931-6.
[8] Tominaga K, Hongo N, et al. Cosmetic benefits of astaxanthin on human subjects. ACTABP. 2012;59(1):43-47.
[9] Ikeuchi M, Koyama T, Takahashi J, Yazawa K. Effects of astaxanthin supplementation on exercise-induced fatigue in mice. Biol Pharm Bull. 2006;29(10):2106-10.
[10] Hussein G, Goto H, Oda S, et al. Antihypertensive potential and mechanism of action of astaxanthin: III. Antioxidant and histopathological effects in spontaneously hypertensive rats. Biol Pharm Bull. 2006;29(4):684-8.
[11] Naguib YM. Antioxidant activities of astaxanthin and related carotenoids. J Agric Food Chem. 2000;48(4):1150-4.

CW Hyaluronic Acid

[1] Bukhari SNA, Roswandi NL, et al. Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects. Int J Biol Macromol. 2018;120(Pt B):1682-1695.
[12] Murray JC, Burch JA, et al. A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation. Int J Cosmet Sci. 2004;26(5):231-8. J Am Acad Dermatol. 2008;59(3):418-25.
[13] Pietta PG. Flavonoids as antioxidants. J Nat Prod. 2000;63:1035-1042
[14]Paiva SA, Russell RM. Beta-carotene and other carotenoids as antioxidants. J Am Coll Nutr. 1999;18(5):426-33.
[15] Korać RR, Khambholja KM. Potential of herbs in skin protection from ultraviolet radiation. Pharmacogn Rev. 2011;5(10):164-73.
[16] Pazyar N, Yaghoobi R, et al. Jojoba in dermatology: a succinct review. G Ital Dermatol Venereol. 2013;148(6):687-91.
[17] Hajhashemi M, Rafieian M, et al. The effect of Aloe vera gel and sweet almond oil on striae gravidarum in nulliparous women. J Matern Fetal Neonatal Med. 2018;31(13):1703-1708.